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GENXMAP
GENXMAP
GENXMAP
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Genetic Mapping Package

Precise tool to decode molecular regulations and interactions

Cartographie_genique-Genxmap

0.1%

Variant detection sensitivity with digital PCR (dPCR)

>99.9%

Sequencing accuracy using Sanger sequencing (gold-standard validation)

~20k

Coding genes covered by Whole Exome Sequencing (WES)

Available Genetic Mapping Options:

Targeted genotyping

  • Conventional PCR and qPCR

  • Digital PCR (dPCR)

  • Sanger sequencing

In-depth genomic mapping

  • Whole Genome Sequencing (WGS)

  • Whole Exome Sequencing (WES)

Why Choose Our Genetic Mapping Package?

✅ Methods tailored to each level of analysis
✅ Maximum precision to validate your genetic modifications
✅ An integrated workflow from extraction to bioinformatics analysis
✅ Tailored scientific support at every step

In-depth genetic structure analysis – Locating, validating, and interpreting genetic variations

A key approach to understanding the genome

Genetic mapping consists of precisely identifying and locating genes and their variations within the genome. It plays a central role in several scientific fields, particularly in biomedical research, where it enables the identification of genetic factors involved in diseases, a better understanding of their clinical impact, and the orientation of therapeutic strategies.

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It is also widely used in animal model studies to verify transgene integration and characterize the genotype of specific strains. Finally, in the context of gene therapies and genome editing technologies such as CRISPR-Cas9, mapping is essential to validate the precision of the induced modifications.

GENXMAP’s Genetic Mapping Packages

We offer two complementary service levels, depending on the desired depth of analysis:

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Targeted genotyping using conventional and precision methods

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Conventional PCR / qPCR:
For the rapid and reliable detection of simple mutations (insertions, deletions, SNPs).

Digital PCR (dPCR):
For absolute and ultra-sensitive quantification of rare variants, even at low abundance.

Sanger sequencing:
The gold-standard method for validating point mutations or confirming genetic edits (CRISPR/Cas9, knock-in/out).

In-depth genomic mapping through high-throughput sequencing
 
Whole Genome Sequencing (WGS):
A comprehensive analysis of the entire genome, enabling the identification of all genetic variations within a given cohort or model.
Whole Exome Sequencing (WES):
Targeted sequencing of coding regions (exons) to detect mutations with a direct impact on proteins — highly valuable in clinical research, medical genetics, and functional pathology.

Comprehensive DNA Analysis Solutions — From Targeted to Genome-wide

Accurate methods to detect, measure, and map DNA
1. DNA Extraction & Quality Control

Obtain high-quality DNA extracts, essential for your genetic mapping analyses
 

Applications:
Genomic DNA (gDNA) extraction from diverse matrices (whole blood, PBMC, fresh or fixed tissues, cell cultures, environmental samples), with quality and concentration verification prior to PCR, Sanger sequencing, WES, or WGS.
 

Techniques:

  • Optimized extraction kits (silica columns or magnetic beads) with protocols adapted to sample type and analytical objectives

  • Nanodrop: rapid measurement of concentration and purity (260/280 and 260/230 ratios)

  • Qubit: sensitive and precise quantification, even at low concentrations

  • TapeStation / Fragment Analyzer: evaluation of DNA integrity (DIN), essential for high-throughput sequencing applications (WGS/WES)

2. Sample / Library Preparation

Guaranteed quality for your libraries
 

Applications:
Preparation of samples for a wide range of approaches: targeted PCR, qPCR, digital PCR (dPCR), Sanger sequencing, targeted panels, Whole Exome Sequencing (WES), or Whole Genome Sequencing (WGS). Verification of library quality and fragment size prior to sequencing or molecular detection.
 

Techniques:

  • Protocols adapted to the type of analysis: conventional PCR/qPCR (SYBR Green, TaqMan), compartmentalized dPCR, Illumina libraries (WES/WGS, targeted panels)

  • Purification steps and inhibitor removal to ensure specificity and reproducibility

  • Qubit: precise quantification of libraries

  • Library-specific qPCR: estimation of sequencing-ready library amounts

  • TapeStation / Fragment Analyzer: assessment of fragment size, detection of potential dimers, and overall library quality control

3. Sequencing / Detection

Multitechnique sequencing and detection for genomic mapping

Applications:
Targeted validation (PCR, qPCR, dPCR, Sanger) or large-scale analyses (WES, WGS) for the identification of variants, rare mutations, genetic profiles, or specific signatures.

Techniques:

  • Conventional PCR/qPCR: targeted amplification and detection

  • dPCR: absolute quantification in copies/µL

  • Sanger sequencing: point validation of target genes

  • WES: sequencing of coding exomes

  • WGS: whole-genome sequencing (Illumina NovaSeq or equivalent)

4. Genetic and Molecular Analyses

Obtain reliable and comprehensive results.
 

Applications:
Identification and characterization of genetic variations (SNPs, indels, CNVs) from sequencing or detection methods. Validation of mutations or rare variants and integration with clinical or functional databases to assess their impact in biomedical research, medical genetics, or molecular biology.
 

Techniques:

  • Variant calling from WES/WGS data

  • Functional annotation using reference databases (ClinVar, dbSNP, COSMIC, OMIM)

  • Comparative analyses across experimental groups (patients vs controls, pre/post-treatment)

  • Cross-validation via PCR, dPCR or Sanger sequencing

  • Integrative analyses combining genetic, transcriptomic, or clinical datasets

Our All-in-One Packages

Optimized, ready-to-use workflows...
Our Solutions, Your Project!
Package Génotypage-Genxmap
Targeted Genotyping Package
Check our shop for pricing and ordering options.
*For any order ≥ 48 samples

Proposed Configuration
 

  • Target: Specific genes or regions of interest

  • Samples: Genomic DNA extracted from whole blood, PBMC, fresh/fixed tissues, or cultured cells

  • Methodology:

    • DNA extraction & QC (DIN ≥7, Qubit, Nanodrop)

    • Conventional PCR or qPCR with specific primers

    • Fluorescence-based detection (SYBR Green)

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  • Analyses: Targeted amplification → variant detection → relative quantification

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  • Deliverables: Raw data (amplification curves / chromatograms) + result tables (Ct values, relative ratios) + summary PDF report


​Options: Multiplexing, reference gene stability analysis, co-analysis with clinical data
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Package PCR-qPCR-Genxmap
Conventional PCR and qPCR Package
Check our shop for pricing and ordering options.
*For any order ≥ 96 samples

Proposed Configuration
 

  • Target: Genes of interest + reference genes

  • Samples: Genomic DNA 

  • Methodology:

    • Conventional PCR: amplification and visualization on gel

    • qPCR: real-time amplification (SYBR Green / TaqMan, ΔΔCt method)

    • Sample QC: purity and absence of inhibitors
       

  • Analyses: Targeted amplification → variant detection 
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  • Deliverables: Amplification curves, Ct tables, graphs (barplots/boxplots), PDF report
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Options: Multiplex qPCR, reference gene stability analysis

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Package PCR Digitale-Genxmap
Digital PCR (dPCR) Package
Check our shop for pricing and ordering options.
*For any order ≥ 48 samples

Proposed Configuration
 

  • Target: Genes of interest for absolute quantification

  • Samples: DNA 

  • Methodology:

    • Sample partitioning (microfluidic)

    • Digital amplification with specific fluorescent probes (TaqMan)

    • Binary detection (positive/negative)
       

  • Analyses: Positive/negative counting → absolute concentration in copies/µL → ratios between targets
     

  • Deliverables: Absolute values (copies/µL), result tables, quantification graphs, PDF report
     

Options: Rare mutation detection, biomarker validation, multiplexing

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Package Sequencage Sanger-Genxmap
Sanger Sequencing Package
Check our shop for pricing and ordering options.
*For any order ≥ 96 samples

Proposed Configuration
 

  • Target: Genes or short fragments (≤ 1 kb)

  • Samples: Genomic DNA or purified PCR products

  • Methodology:

    • Targeted PCR amplification

    • Sanger sequencing (capillary electrophoresis)

    • Chromatogram inspection and base quality check
       

  • Analyses: Point validation of variants, mutations, or target genes
     

 

  • Deliverables: Raw files (AB1), aligned sequences (FASTA/FASTQ), annotated chromatograms, PDF report


Options: Validation of variants detected by NGS, bidirectional analysis

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Package Whole Exome Sequencing (WES)-Genxmap
Whole Exome Sequencing (WES) Package
Check our shop for pricing and ordering options.
*For any order ≥ 24 samples

Proposed Configuration
 

  • Target: Coding exome (~1–2% of the genome)

  • Samples: Genomic DNA (blood, PBMC, tissues)

  • Methodology:

    • DNA extraction & QC (DIN)

    • Capture of coding exons (enrichment kits)

    • Illumina library preparation

    • NovaSeq / NextSeq sequencing (2×150 bp, ≥10–15 Gb / sample)
       

  • Analyses: Read QC → genome alignment → variant calling (SNVs, indels) → annotation (dbSNP, ClinVar, COSMIC)
     

  • Deliverables: FASTQ + BAM/BAI + VCF (variants) + QC reports + PDF summary report
     

Options: Increased sequencing depth, co-analysis with RNA-seq, extended functional annotation

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Package Whole Genome Sequencing (WGS)-Genxmap
Whole Genome Sequencing (WGS) Package
Check our shop for pricing and ordering options.
*For any order ≥ 24 samples

Proposed Configuration
 

  • Target: Whole genome

  • Samples: High-integrity genomic DNA

  • Methodology:

    • DNA extraction & QC

    • Shotgun library preparation (Illumina)

    • NovaSeq 6000 sequencing (2×150 bp, ≥30× standard coverage)
       

  • Analyses: Read QC → genome alignment → variant calling (SNVs, indels, CNVs, SVs) → functional and comparative annotation
     

  • Deliverables: FASTQ + BAM/BAI + VCF + QC reports + PDF summary report + figures (circos, CNV plots)
     

Options: Deep coverage (60–100×), long-read sequencing (ONT, PacBio), multi-omics co-analysis

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Package Cartographie génomique approfondie-Genxmap
Targeted NGS / Panels Package
Check our shop for pricing and ordering options.
*For any order ≥ 48 samples

Proposed Configuration

  • Target: Specific genomic regions (oncogenes, rare diseases, pharmacogenetics, etc.)

  • Samples: Genomic DNA (blood, PBMC, tissues, cells)

  • Methodology:

    • DNA extraction & QC

    • Target enrichment ( amplicons)

    • Dual-indexed library preparation

    • Illumina sequencing (MiSeq / 2×250 bp)

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  • Analyses: Read QC → alignment (BWA) → variant calling (SNVs, indels) → functional annotation → custom filtering → visualization

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  • Deliverables: FASTQ + annotated VCFs + BAM/BAI + coverage reports + tabulated files + PDF summary report


Options: Custom panels, CNV detection, multi-sample analysis, integration with RNA-seq or phenotyping

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Kickstart your project today

Tell us what you need — we’ll get back to you with a bespoke solution.

Our DNA

We leverage our expertise and technologies to help our partners and clients turn biological complexity into reliable, actionable data.

From method to impact

Discover how we work at GENXMAP

Our solutions

Precise and advanced services, cutting-edge technologies, and reliable analyses.
Our rigorous approach ensures detailed results, essential for your scientific discoveries and clinical applications.

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