Transcriptomic Biomarker Analysis – COVID-19

COVID-19, caused by the SARS-CoV-2 virus, has led to a global pandemic with severe public health impacts. Gene expression analysis in infected patients helps to better understand the immune response, identify severity biomarkers, and support the development of targeted treatments.

Genes Analyzed in COVID-19

Our panel targets key biomarkers associated with immune response, systemic inflammation, and immune cell activation, including:

• IL-6 – Pro-inflammatory cytokine involved in the cytokine storm observed in severe COVID-19 cases

• TNF-α – Key pro-inflammatory cytokine in the acute immune response to SARS-CoV-2 infection

• CXCL10 (IP-10) – Chemokine associated with inflammation and immune cell recruitment in lung tissues

• IFN-β (Interferon-beta) – Key antiviral cytokine in innate immunity, often impaired in severe COVID-19 cases

• ACE2 (Angiotensin-Converting Enzyme 2) – Critical receptor for SARS-CoV-2 entry into human cells, particularly in lung cells

• TGF-β – Cytokine involved in inflammation regulation and tissue healing, altered in severe COVID-19 cases

• CD4+ and CD8+ T lymphocytes – Adaptive immune response markers linked to infection control

• MMP-9 – Enzyme involved in extracellular matrix degradation, associated with lung inflammation and tissue damage

Applications & Benefits

• Identification of Severity Biomarkers – Predicting severe COVID-19 cases and preventing complications

• Monitoring Inflammatory Activity and Disease Progression

• Prediction of Treatment Response – Identifying high-risk patients for targeted therapeutic strategies

• Evaluation of Post-Infection Immunity and Vaccine Response – Optimizing patient management and vaccination strategies

• Characterization of Biomarkers for Acute Infection and Post-COVID Conditions

Technologies Used

• RT-qPCR and RNA-seq (NGS) – Quantitative analysis of immune and inflammatory gene expression

• Nanostring and Transcriptomic Microarrays – Multiplexed analysis detecting multiple severity-associated biomarkers

• Transcriptomic Signature Analysis – Identifying immune response, healing, and infection progression markers

Contact us at contact@genxmap.com for an in-depth and personalized analysis of COVID-19 biomarkers to improve infection management!