Transcriptomic Biomarker Analysis – Crohn's Disease and Ulcerative Colitis (UC)

Chronic inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis (UC), are characterized by chronic inflammation of the gastrointestinal tract. Gene expression analysis allows the identification of biomarkers for diagnosis, disease monitoring, and treatment personalization.

Genes Analyzed in Crohn's Disease and UC

Our panels target key biomarkers associated with intestinal inflammation, microbiome dysbiosis, and immune response, including:

• NOD2 (Nucleotide-binding oligomerization domain containing 2) – Gene involved in innate immune response, often mutated in Crohn's disease

• ATG16L1 – Gene linked to autophagy regulation, a crucial process in the inflammatory response

• IL-23R – Cytokine receptor involved in inflammation and Crohn's disease development

• TNF-α (Tumor Necrosis Factor alpha) – Key pro-inflammatory cytokine in UC and Crohn's disease

• IL-6 and IL-1β – Cytokines involved in mediating inflammation in IBD

• JAK2 – Cytokine receptor involved in signaling and regulating the immune response

• MUC2 (Mucin 2) – Gene involved in mucus production in the intestines, often altered in UC

• TGF-β – Key anti-inflammatory cytokine in immune response regulation and tissue repair

Applications & Benefits

• Early diagnosis and differentiation between Crohn's disease and UC

• Monitoring of inflammatory activity in IBD and assessment of flare-ups

• Prediction of response to anti-TNF, corticosteroids, and other targeted therapies

• Identification of new biomarkers to predict complications, such as fistulas in Crohn's disease

• Personalization of treatments based on patients' transcriptomic profiles

Technologies Used

We use advanced technologies for accurate and reliable analysis:

• RT-qPCR and RNA-seq (NGS) to quantify gene expression associated with inflammation and dysbiosis

• Nanostring and transcriptomic arrays to analyze multiple biomarkers simultaneously

• Analysis of microbial profiles and immune signatures associated with active or remitting disease forms

Contact us at contat@genxmap.com for a personalized analysis of Crohn's disease and UC to better understand underlying biomarkers and personalize treatments!