Transcriptomic Biomarker Analysis – HIV (Human Immunodeficiency Virus)

HIV (Human Immunodeficiency Virus) progressively destroys the immune system, leading to the development of AIDS (Acquired Immunodeficiency Syndrome). Gene expression analysis in HIV-infected patients provides insights into infection progression, immune response, and antiretroviral treatment efficacy.

Genes Analyzed in HIV

Our panel targets key biomarkers associated with immune response, inflammation, and HIV progression, including:

• CD4+ T lymphocytes – Primary target of HIV; their count is a key indicator of immune status and treatment effectiveness

• CCR5 & CXCR4 – Receptors used by HIV to enter host cells, studied to predict infection patterns and treatment resistance

• IFN-γ (Interferon-gamma) – Cytokine produced by T lymphocytes and NK cells, essential for antiviral immune response

• TNF-α – Pro-inflammatory cytokine linked to HIV progression and immune system activation

• IL-6 – Pro-inflammatory cytokine often elevated in chronic infections, including HIV, and associated with disease progression

• IP-10 (CXCL10) – Chemokine involved in inflammation and immune cell recruitment to infected tissues

• Viral Load – Quantification of viral RNA in the blood, used as a biomarker to assess HIV activity and antiretroviral treatment efficacy

• TGF-β – Cytokine regulating inflammation and immune dysfunction in HIV

• Bcl-2 – Protein involved in cell survival regulation and immune cell management in HIV-infected individuals

Applications & Benefits

• Monitoring viral load and evaluating response to antiretroviral therapy (ART)

• Assessing immune status through CD4+ lymphocyte measurement and cytokine quantification

• Identifying progression biomarkers to predict infection evolution toward AIDS

• Predicting resistant HIV strains and adapting therapeutic strategies (CCR5/CXCR4 receptor mutations)

• Personalizing treatments to enhance antiviral therapy efficacy and minimize side effects

Technologies Used

We use advanced technologies for precise HIV biomarker analysis:

• RT-qPCR and RNA-seq (NGS) to measure gene expression related to immune response and inflammation in HIV+ patient samples

• Nanostring and transcriptomic arrays for multiplex biomarker analysis, enabling comprehensive detection of transcriptomic signatures linked to HIV progression

• Quantitative PCR for viral load assessment to determine treatment efficacy and resistance risks

Contact us at info@genxmap.com for a detailed and personalized HIV biomarker analysis and optimized treatment strategies!