Transcriptomic Biomarker Analysis – Systemic Lupus Erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect multiple organs and systems in the body. Gene expression analysis helps to better understand the immunopathological mechanisms of the disease, identify specific biomarkers, and monitor clinical progression to adjust treatments.

Genes Analyzed in Systemic Lupus Erythematosus

Our panel targets key biomarkers associated with immune activation, inflammation, and dysfunctions in immune system regulation, including:

• IFNα (Interferon alpha) – Key cytokine involved in lupus pathogenesis and biomarker for immune system activation

• TNF-α – Pro-inflammatory cytokine involved in tissue damage and pathology

• IL-6, IL-10 – Cytokines influencing immune response and inflammation in SLE

• BLyS (B lymphocyte stimulator) – Key factor in the development and survival of B cells, involved in autoimmunity

• Fas/FasL – Proteins regulating apoptosis of immune cells, a key mechanism in controlling autoimmunity

• DNase I – Enzyme involved in the degradation of DNA released by dead cells, deficiency associated with SLE

• APOE – Gene involved in lipid metabolism regulation, associated with genetic susceptibility to SLE

Applications & Benefits

• Identification of specific biomarkers for faster and more accurate diagnosis of SLE

• Monitoring disease activity and identifying periods of inflammatory flare-ups

• Personalization of treatment based on patients' transcriptomic profiles

• Assessment of risks associated with organ manifestations (renal, cardiac, neurological)

Technologies Used

We use advanced technologies to ensure high-quality analysis:

• RT-qPCR and RNA-seq (NGS) for precise quantification of gene expression levels associated with inflammation and immune activation

• Nanostring and transcriptomic arrays for multiplexed biomarker evaluation

• Validated transcriptomic signatures to predict treatment response and relapse risk

Contact us at contact@genxmap.com for a thorough and personalized analysis of systemic lupus erythematosus!