Transcriptomic Biomarker Analysis – Multiple Sclerosis (MS)

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, leading to inflammatory and degenerative lesions. Gene expression analysis helps to better understand immunopathological mechanisms and identify biomarkers for diagnosis, prognosis, and patient monitoring.

Genes Analyzed in Multiple Sclerosis

Our panel targets key biomarkers associated with inflammation, demyelination, and neurodegeneration, including:

• IL-17A, IL-23R – Cytokines involved in inflammation and immune response in MS

• CD4+ and CD8+ – T lymphocytes, main players in autoimmune attacks

• HLA-DRB1 – Major gene involved in genetic susceptibility to MS

• CXCR3, CCR5 – Receptors associated with immune cell migration to CNS lesions

• MOG (Myelin Oligodendrocyte Glycoprotein) – Biomarker of demyelination, used to differentiate MS from other disorders

• MBP (Myelin Basic Protein) – Myelin structural protein, marker of demyelination

Applications & Benefits

• Identification of biomarkers for early MS diagnosis

• Monitoring inflammatory activity and disease progression

• Prediction of treatment response and tracking disease evolution

• Identification of patients at risk of developing a more aggressive form of MS

Technologies Used

We employ advanced technologies for reliable and reproducible analysis:

• RT-qPCR and RNA-seq (NGS) for precise evaluation of inflammatory and neurodegenerative gene expression

• Nanostring and transcriptomic arrays for multiplex biomarker analysis

• Immune signature analysis and cytokine profiling

Contact us at contact@genxmap.com for a customized analysis tailored to your neurological research or clinical projects!