Transcriptomic Biomarker Analysis – Psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by erythematous and scaly lesions due to accelerated cell turnover. Gene expression analysis helps to better understand the immunopathological mechanisms of psoriasis, identify biomarkers for diagnosis and monitoring, and personalize therapeutic strategies.

Genes Analyzed in Psoriasis

Our panel targets key biomarkers associated with skin inflammation, immune cell activation, and cell proliferation, including:

• TNF-α (Tumor Necrosis Factor alpha) – Key cytokine mediating inflammation and psoriatic plaque formation

• IL-17A, IL-23 – Cytokines involved in immune response and psoriasis pathogenesis, particularly in plaque psoriasis

• IL-6 – Pro-inflammatory cytokine involved in keratinocyte activation and the spread of skin inflammation

• CD4+ and CD8+ – T lymphocytes playing a major role in inflammation and autoimmunity in psoriasis

• Th17 cytokines – Group of cytokines involved in inflammatory response and keratinocyte activation in psoriatic lesions

• S100A7 – Protein involved in skin inflammation regulation and associated with skin cell proliferation

• KRT16 (Keratin 16) – Gene linked to keratinocyte growth and differentiation, often overexpressed in psoriatic lesions

Applications & Benefits

• Early diagnosis and differentiation of inflammatory forms of psoriasis

• Monitoring inflammatory activity and disease relapses or remissions

• Prediction of treatment response to biologics, particularly anti-TNF and anti-IL-17 therapies

• Identification of severity biomarkers to enable personalized disease management

• Genetic susceptibility analysis to better target psoriasis treatments

Technologies Used

We use advanced technologies for reliable and reproducible analyses:

• RT-qPCR and RNA-seq (NGS) for quantifying inflammatory and proliferative gene expression in skin lesions

• Nanostring and transcriptomic arrays for multiplex biomarker analysis and targeted approaches

• Transcriptomic signature analysis associated with cutaneous psoriasis and treatment response

Contact us at contact@genxmap.com for an in-depth, personalized analysis of your psoriasis project and biomarker management!