Transcriptomic Biomarker Analysis – Rheumatoid Arthritis (RA)

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting the joints, with potential systemic effects. Gene expression analysis helps elucidate immunopathological mechanisms, identify specific biomarkers, and enhance diagnostic and therapeutic strategies.

Genes Analyzed in Rheumatoid Arthritis

Our panel targets key biomarkers associated with inflammation, immune cell activation, and cartilage degradation, including:

• TNF-α (Tumor Necrosis Factor-alpha) – Key cytokine mediating inflammation and RA progression

• IL-6 – Pro-inflammatory cytokine involved in immune response and clinical symptoms

• HLA-DRB1 – Genetic susceptibility gene for RA, known as the "risk gene"

• RANKL – Protein involved in osteoclast activation and bone resorption in RA

• MMP-3 (Matrix Metalloproteinase 3) – Enzyme responsible for cartilage degradation and joint destruction

• PADI4 – Gene involved in protein citrullination, a key process in autoantibody formation against citrullinated proteins (ACPA)

• ACPA (Anti-Citrullinated Protein Antibodies) – RA-specific antibodies used as diagnostic biomarkers

Applications & Benefits

• Early diagnosis and identification of rapidly progressing RA forms

• Monitoring joint inflammation and disease activity

• Risk assessment for joint damage and deformity

• Predicting treatment response (anti-TNF drugs, DMARDs)

• Identifying patients with specific genetic profiles, enabling personalized therapeutic approaches

Technologies Used

We leverage cutting-edge technologies to ensure precise and reliable biomarker analysis:

• RT-qPCR and RNA-seq (NGS) for quantifying genes linked to inflammation and cartilage degradation

• Nanostring and transcriptomic arrays for multiplex biomarker analysis

• Evaluation of transcriptomic signatures associated with treatment response and disease progression

Contact us at contact@genxmap.com for in-depth, personalized analysis tailored to your rheumatology research projects!