Skin Sensitivity and Allergy Analysis – Transcriptomic Biomarkers

Skin sensitivity and allergies can be influenced by genetic, environmental, and immunological factors. Gene expression analysis helps identify biomarkers associated with skin and allergic reactions, providing a better understanding of the underlying mechanisms and optimizing treatments.

Genes Analyzed in Skin Sensitivity and Allergies

Our panel targets key biomarkers associated with immune response, inflammation, and the skin barrier, including:

• FLG (Filaggrin) – Essential protein for the skin barrier, whose degradation can lead to sensitive skin and skin allergies (eczema, dermatitis)

• IL-4 (Interleukin 4) – Cytokine involved in allergic responses, often associated with skin diseases such as eczema and asthma

• IL-13 (Interleukin 13) – Cytokine playing a key role in allergic inflammation and skin response to allergens

• TSLP (Thymic Stromal Lymphopoietin) – Cytokine promoting allergic inflammation and activating immune cells in skin reactions

• CD14 (Cluster of Differentiation 14) – Receptor involved in immune response and pathogen detection, often linked to skin inflammatory responses

• MMP-9 (Matrix Metalloproteinase 9) – Enzyme involved in extracellular matrix degradation, active in skin inflammatory reactions related to allergies

• CYP1A1 (Cytochrome P450 1A1) – Metabolic enzyme associated with allergic and skin responses to environmental toxins

• EPO (Erythropoietin) – Protein involved in inflammation regulation and tissue repair, influencing skin sensitivity

• TNF-α (Tumor Necrosis Factor Alpha) – Inflammatory cytokine involved in allergic skin reactions and skin pathologies

• C5 (Complement Component 5) – Protein of the complement system, playing a role in allergic responses and skin inflammation

Applications & Benefits

• Diagnosis and Management of Skin Allergies: Biomarker analysis helps identify patients predisposed to skin allergic reactions and better understand the involved mechanisms

• Personalization of Anti-Allergic Treatments: Based on gene expression, treatments for skin allergies can be personalized, adjusting topical or systemic therapies

• Monitoring Sensitive Skin Treatments: Tracking treatments to improve skin barrier function and reduce inflammation in conditions such as eczema or dermatitis

• Prevention of Allergic Reactions: Identifying biomarkers that predict the risk of allergic skin reactions following exposure to environmental allergens

• Understanding Environmental Factors: Studying the influence of exposure to allergens, chemicals, and pollution on skin sensitivity and allergies

Technologies Used

We use advanced technologies for precise analysis of biomarkers associated with skin sensitivity and allergies:

• RT-qPCR and RNA-seq (NGS) to quantify gene expression linked to inflammation and immune response

• Immunohistochemistry to measure protein expression associated with the skin barrier and allergic response

• Multiplex technologies (e.g., Nanostring) for simultaneous analysis of biomarkers related to skin allergies

• Clinical tests to evaluate the impact of treatments on the expression of allergic and skin genes

Contact us at contact@genxmap.com for a personalized analysis of skin sensitivity and allergies to optimize your dermatological and allergic management!