Skin Aging Analysis – Transcriptomic Biomarkers

Skin aging is a complex process influenced by internal factors (genetics, hormones) and external factors (sun exposure, pollution). Gene expression analysis helps identify biomarkers linked to elasticity loss, collagen degradation, and wrinkle formation, providing deeper insight into the cellular mechanisms of skin aging.

Genes Analyzed in Skin Aging

Our panel targets key biomarkers associated with extracellular matrix degradation, inflammation, and skin radiance, including:

• COL1A1 (Collagen Type I Alpha 1 Chain) – Essential for collagen synthesis, a key protein for skin structure and firmness

• MMP-1 (Matrix Metalloproteinase 1) – Enzyme responsible for collagen breakdown, accelerating skin aging

• TGF-β (Transforming Growth Factor Beta) – Cytokine involved in tissue repair and collagen regulation; imbalance can lead to skin laxity

• IL-6 (Interleukin 6) – Inflammatory cytokine linked to premature skin aging and chronic skin inflammation

• SIRT1 (Sirtuin 1) – Protein involved in DNA repair and cellular longevity, protecting against skin damage

• TP53 (Tumor Protein 53) – Regulates DNA repair and prevents premature cellular aging

• APOE (Apolipoprotein E) – Associated with cellular damage repair and inflammatory processes, influencing skin aging speed

• FAS (Fas Cell Surface Death Receptor) – Apoptotic signaling receptor regulating cell renewal and skin regeneration

• VDR (Vitamin D Receptor) – Essential for skin metabolism and cell growth regulation

Applications & Benefits

• Skin Aging Assessment – Identifying biological mechanisms and early aging signs

• Optimization of Anti-Aging Treatments – Personalizing skincare based on collagen and repair-related gene expression

• Monitoring Dermatological Treatments – Evaluating the effectiveness of skin regeneration and wrinkle reduction treatments

• Prevention of Premature Aging – Early interventions based on biomarker identification

• Understanding Environmental Factors – Studying how external influences (sun exposure, pollution, lifestyle) impact gene expression in skin aging

Technologies Used

• RT-qPCR and RNA-seq (NGS) – Quantifying gene expression related to extracellular matrix, inflammation, and skin regeneration

• Nanostring and Transcriptomic Microarrays – Multiplex biomarker analysis for anti-aging research

• Immunohistochemistry – Measuring protein expression linked to skin structure, such as collagen and degradation enzymes

• Clinical Evaluations – Assessing treatment impact on skin aging-related genes

Contact us at contact@genxmap.com for a personalized skin aging analysis and targeted skincare approach!