Program 01 · Internal Research
Every single-cell RNA-seq method in routine use today starts the same way: the cell is lysed. It's a one-shot, destructive snapshot. GenXMap is building a live single-cell omics method to read transcriptomic state from an intact, living cell, opening the door to real kinetics at single-cell resolution.
Single-cell transcriptomics has transformed biology, but every established protocol destroys the cell to read it. That means you get one timepoint per cell, ever: no re-sampling, no kinetics, no way to watch the same cell change state and later confirm what it became. For biological questions that unfold over time (a cell responding to a drug, a rare clone drifting toward resistance, an immune cell differentiating) that one-shot limit is the ceiling.
Cell isolated → lysed → RNA captured → sequenced. Destructive by design. Every timepoint requires a fresh, separate cell: and population-level inference stands in for true single-cell kinetics.
A method to extract transcriptomic signal from a single living cell without lysis, preserving viability so the same cell can be measured again, tracked, or recovered for downstream use.
Removing the lysis step doesn't just save a sample. It changes what questions are answerable. Longitudinal single-cell data, paired before/after measurements on the same cell, and downstream functional assays on cells that were previously "read" all become possible for the first time at single-cell resolution.
A multi-year internal research program moving from early feasibility work through validation and, ultimately, integration into GenXMap's platform. We keep programme-stage detail out of the public domain while IP and partnership discussions are ongoing, get in touch for a deeper briefing under NDA.
This program is supported by public innovation funding and the Marseille biotech ecosystem, reflecting the scientific and strategic value placed on non-destructive single-cell omics as a future research infrastructure.
Funding & support
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